Drug Intermediates

The present invention is directed towards a method of ultrasensitive detection and quantification of primary 5 amines by reaction of the primary amine with substituted aroyl-2-quinoline-carboxaldehyde (XArQCA) reagents, followed by measurement of the fluorescent product. Primary amines which may be detected by the present reagents include naturally occurring and chemically synthesized molecules such.

Novel N-methylated 2-(oxazolin-2-yl)-4,4-bipyridinium salts, bearing a chiral oxazoline moiety, were tested in the Rh(I)-catalysed enantioselective hydrosilylation. After coordination to rhodium these electron-attracting ligands are supposed to exhibit charge-transfer effects with electron-donating substrates.

4-methoxybenzoic acid, or anisic acid, is an organic compound which is a carboxylic acid found naturally in anise. It is a white crystalline solid which is insoluble in water and soluble in alcohols, ether, and ethyl acetate.

4-Methoxybenzoic acid, or anisic acid, is an organic compound which is a carboxylic acid found naturally in anise. It is a white crystalline solid which is insoluble in water and soluble in alcohols, ether, and ethyl acetate.

3,5-Dinitrosalicylic acid (DNS) is an aromatic compound that reacts with reducing sugars and other reducing molecules to form 3-amino-5-nitrosalicylic acid, which absorbs light strongly at 540 nm. It was first introduced as a method to detect reducing substances in urine and has since been widely used, for example, for quantificating carbohydrates levels in blood. It is mainly used in assay of alpha-amylase. However, enzymatic methods are usually preferred to DNS due to their specificity.

Dimethoxybenzene is useful as an intermediate in synthesis of pharmaceuticals as well as other organic molecules. It is used in some paints and as a diazo dye. Cosmetically it is used on greasy skin, and with sulfur to treat acne, or as a dandruff treatment.