Plasticizers

Spin-lattice relaxation times and nuclear overhauser enhancement factors (noe) for the individual ring carbons in di-methyl phthalate (dmf) were measured over a wide range of temperatures. The results show that the reorientational correlation function corresponding to the global dynamics in supercooled liquid can be well described by a davidson-cole distribution. The viscosity dependence of the reorientational correlation time derived is analysed to investigate the adequacy of the modified debye equation to description of the microscopic behaviour of supercooled systems

The main source of information for this fact sheet is epa's health and environmental effects profile for phthalic acid alkyl, aryl, and alkyl/aryl esters. Other secondary sources include the hazardous substances data bank (hsdb), a database of summaries of peer-reviewed literature, and the registry of toxic effects of chemical substances (rtecs), a database of toxic effects that are not peer reviewed.

Breakdown product of dimethyl phthalate, used in insect repellant, plastic, rocket propellant; fetal and adult exposures linked to male reproductive issues.

A compound of the general formula (I) : as well as any optical or geometric isomer or tautomeric form thereof including mixtures of these or a pharmaceutically acceptable basic organic or inorganic addition salt or hydrate or prodrug hereof, wherein A is-O-,-S-, >SO, >S02, >CO, >CR9R10, or >NR11 ; R1 and R2 independently are one of the following groups: hydrogen.

Diethylphthalate and dimethylphthalate are used as phthalate plasticizers, in an extensive array of products. The chronic dermal toxicity of diethylphthalate was evaluated in male and female F344/N rats and B6C3F1 mice in 2-year studies. In a series of special studies, the tumor initiation or promotion potential of diethylphthalate or dimethylphthalate was evaluated in male Swiss (CD-1®) mice by an initiation/promotion model of skin carcinogenesis. The genetic toxicity of diethylphthalate and dimethylphthalate in Salmonella typhimurium and cultured Chinese hamster ovary cells was also evaluated.

Waldo Semon and the B.F. Goodrich Company developed a method in 1926 to plasticize PVC by blending it with various additives. The result was a more flexible and more easily processed material that soon achieved widespread commercial use.